The Association between Disturbed Eating Behavior and Socioeconomic Status: The Online Korean Adolescent Panel Survey (OnKAPS)

Background: A limited amount of research, primarily conducted in Western countries, has suggested that higher socioeconomic status (SES) is associated with higher risk of eating disorders (EDs). However, little is known about this association in Asian countries. We examined the association of SES with disturbed eating behavior (DEB) and related factors in Korean adolescents. Subjects A nationwide online panel survey was conducted in a sample of adolescents (n = 6,943, 49.9% girls). DEB was measured with the 26-item Eating Attitudes Test (EAT-26). Participants who scored ≥20 on the EAT-26 were considered to have DEB. Participants’ SES was determined based on self-reported household economic status. Results: The prevalence of DEB was 12.7%: 10.5% among boys and 14.8% among girls. Both boys and girls with DEB were more likely to perceive themselves as obese, experience higher levels of stress, and have lower academic achievement. The risk for DEB was significantly higher in boys of higher SES than in those of middle SES (OR = 1.45, 95%CI = 1.05–1.99 for high SES; OR = 5.16, 95%CI: 3.50–7.61 for highest SES). Among girls, higher risk of DEB was associated with the highest and lowest SES (OR = 1.52, 95%CI: 1.13–2.06 for lowest SES; OR = 2.22, 95%CI: 1.34–3.68 for highest SES). Conclusions: Despite the lower prevalence of obesity in Korea compared with Western countries, the prevalence of DEB in Korean adolescents was high, especially among girls. Moreover, the association between SES and DEB followed a U-shaped curve for girls and a J-shaped curve for boys

Lateral resistance of mass timber shear wall connected by withdrawal-type connectors

In this study, the lateral resistances of mass timber shear walls were investigated for seismic design. The lateral resistances were predicted by kinematic models with mechanical properties of connectors, and compared with experimental data. Four out of 7 shear wall specimens consisted of a single Ply-lam panel and withdrawal-type connectors. Three out of 7 shear wall specimens consisted of two panels made by dividing a single panel in half. The divided panels were connected by 2 or 4 connectors like a single panel before being divided. The applied vertical load was 0, 24, or 120 kN, and the number of connectors for connecting the Ply-lam wall-to-floor was 2 or 4. As a result, the tested data were 6.3 to 52.7% higher than the predicted value by kinematic models, and it means that the lateral resistance can be designed by the behavior of the connector, and the prediction will be safe. The effects of wall-to-wall connectors, wall-to-floor connectors and vertical loads on the shear wall were analyzed with the experimental data.This project was funded by the Korea Forest Service (Korea Forestry Promotion Institute) and the Ministry of Land, Infrastructure and Transport (the Korea Agency for Infrastructure Technology Advancement)

Sensitivity of censored data analysis to determine the characteristic value of structural timber

In structural timber tests, unintended failure mechanisms occur frequently in specimens and their results are called censored data. There are two censored data analysis: censored maximum likelihood estimation (CMLE) and Kaplan–Meier (KM) method. In this study, the precision of the censored data analysis was investigated to determine the characteristic value, 5th percentile value, of the structural timber. The results show that (1) the 5th percentile value was underestimated by ordinary data analysis methods; maximum likelihood estimation (MLE) and Order statistics. (2) CMLE with 30% lower tail censored data and KM method provided much more precise 5th percentile value. (3) The amount of under-measurement (5 MPa, 10 MPa, and 15 MPa in this simulation study) did not show significant effect on the 5th percentile determination in CMLE and KM method, but the proportion of censored data (percentage of unintended failure specimen; 10%, 20%, 30%, and 40%) affected the determination of 5th percentile value. (4) CMLE with 30% lower tail censored data and KM method showed good agreement in case that the data included unintended failure data up to 20%.(1) This work was supported by Research Resettlement Fund for the new fac‑ulty of Seoul National University. (2) This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2017R1A2B1010748)

Prediction of withdrawal resistance for a screw in hybrid cross-laminated timber

The aim of this study was to predict the withdrawal resistance of a screw in hybrid cross-laminated timber (CLT) composed of two types of lamina layers. A theoretical model to predict the withdrawal resistance was developed from the shear mechanism between a screw and the layers in hybrid CLT. The parameters for the developed model were the withdrawal stiffness and strength that occurs when a screw is withdrawn, and the penetration depth of a screw in layers of a wood material. The prediction model was validated with an experimental test. Screws with two different diameters and lengths (Ø6.5 × 65mm and Ø8.0 × 100mm) were inserted in a panel composed of solid wood and plywood layers, and the withdrawal resistances of the screws were evaluated. At least 30 specimens for each group were tested to derive the lower 5th percentile values. As a result, the developed model predictions were 86–88% of the lower 5th percentile values of hybrid CLT from the properties of the lamina layer. This shows that the withdrawal resistance of hybrid CLT can be designed from the properties of its layer.This project was funded by the Korea Forest Service (Korea Forestry Promotion Institute) and the Ministry of Land, Infrastructure and Transport (the Korea Agency for Infrastructure Technology Advancement)

Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT

Telomere homeostasis is regulated by telomerase and a collection of associatedproteins. Telomerase is, in turn, regulated by post-translational modifications of the rate-limiting catalytic subunit hTERT. Here we show that disruption of Hsp90 by geldanamycin promotes efficient ubiquitination and proteasome-mediated degradation of hTERT. Furthermore, we have used the yeast two-hybrid method to identify a novel RING finger gene (MKRN1) encoding an E3 ligase that mediates ubiquitination of hTERT. Overexpression of MKRN1 in telomerase-positive cells promotes the degradation of hTERT and decreases telomerase activity and subsequently telomere length. Our data suggest that MKRN1 plays an important role in modulating telomere length homeostasis through a dynamic balance involving hTERT protein stability

Dual Effect of Chrysanthemum indicum

The risk of bone-related diseases increases due to the imbalance between bone resorption and bone formation by osteoclasts and osteoblasts, respectively. The goal in the development of antiosteoporotic treatments is an agent that will improve bone through simultaneous osteoblast stimulation and osteoclast inhibition without undesirable side effects. To achieve this goal, numerous studies have been performed to identify novel approaches using natural oriental herbs to treat bone metabolic diseases. In the present study, we investigated the effect of Chrysanthemum indicum extract (CIE) on the differentiation of osteoclastic and osteoblastic cells. CIE inhibited the formation of TRAP-positive mature osteoclasts and of filamentous-actin rings and disrupted the bone-resorbing activity of mature osteoclasts in a dose-dependent manner. CIE strongly inhibited Akt, GSK3β, and IκB phosphorylation in RANKL-stimulated bone marrow macrophages and did not show any effects on MAP kinases, including p38, ERK, and JNK. Interestingly, CIE also enhanced primary osteoblast differentiation via upregulation of the expression of alkaline phosphatase and the level of extracellular calcium concentrations during the early and terminal stages of differentiation, respectively. Our results revealed that CIE could have a potential therapeutic role in bone-related disorders through its dual effects on osteoclast and osteoblast differentiation

Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer’s Disease

MicroRNAs have emerged as key factors in development, neurogenesis and synaptic functions in the central nervous system. In the present study, we investigated a pathophysiological significance of microRNA-188-5p (miR-188-5p) in Alzheimer’s disease (AD). We found that oligomeric Aβ(1-42) treatment diminished miR-188-5p expression in primary hippocampal neuron cultures and that miR-188-5p rescued the Aβ(1-42)-mediated synapse elimination and synaptic dysfunctions. Moreover, the impairments in cognitive function and synaptic transmission observed in 7-month-old five familial AD (5XFAD) transgenic mice, were ameliorated via viral-mediated expression of miR-188-5p. miR-188-5p expression was down-regulated in the brain tissues from AD patients and 5XFAD mice. The addition of miR-188-5p rescued the reduction in dendritic spine density in the primary hippocampal neurons treated with oligomeric Aβ(1-42) and cultured from 5XFAD mice. The reduction in the frequency of mEPSCs was also restored by addition of miR-188-5p. The impairments in basal fEPSPs and cognition observed in 7-month-old 5XFAD mice were ameliorated via the viral-mediated expression of miR-188-5p in the hippocampus. Furthermore, we found that miR-188 expression is CREB-dependent. Taken together, our results suggest that dysregulation of miR-188-5p expression contributes to the pathogenesis of AD by inducing synaptic dysfunction and cognitive deficits associated with Aβ-mediated pathophysiology in the disease

Inkjet-Printed Carbon Nanotubes for Fabricating a Spoof Fingerprint on Paper.

A spoof fingerprint was fabricated on paper and applied for a spoofing attack to unlock a smartphone on which a capacitive array of sensors had been embedded with a fingerprint recognition algorithm. Using an inkjet printer with an ink made of carbon nanotubes (CNTs), we printed a spoof fingerprint having an electrical and geometric pattern of ridges and furrows comparable to that of the real fingerprint. With this printed spoof fingerprint, we were able to unlock a smartphone successfully; this was due to the good quality of the printed CNT material, which provided electrical conductivities and structural patterns similar to those of the real fingerprint. This result confirms that inkjet-printing CNTs to fabricate a spoof fingerprint on paper is an easy, simple spoofing route from the real fingerprint and suggests a new method for outputting the physical ridges and furrows on a two-dimensional plane